Effects of Grape Juice Consumption on Fatigue and Sleep Quality in Women with Breast Cancer During Radiation Therapy-Controlled Clinical Trial-Pilot Article

Background and Objectives: Fatigue and sleep disturbance are side effects of radiation therapy. Grape juice is a traditional product rich in antioxidants and polyphenols that have been shown to include positive effects on improving fatigue and sleep disorders. The aim of this study was to assess effects of grape juice consumption on fatigue and sleep quality in women with breast cancer undergoing radiation therapy.  Materials & Methods: In this controlled clinical trial, 44 women with breast cancer aged 18–70 years were randomly divided into intervention and control groups. The intervention group consumed 100 g of grape juice daily from the beginning of treatment until five weeks and the control group did not consume any medications or placebo. Fatigue scores and sleep quality were assessed and compared between the two groups at the beginning and end of the study using fatigue questionnaires (MFSI-SF) and sleep quality questionnaires (PSQI). study using fatigue and sleep quality questionnaires(MFSI-SF, PSQI ). Data analysis was carried out using paired t-test and independent t-test. Results: In this study, physical fatigue scales were significantly different between the two groups with the consumption of grape juice (p < 0.05), but the overall fatigue rates were not significant between the two groups (p ≥ 0.05). By examining the scores linked to sleep quality, it was shown that the sleep disorder scale of the intervention group significantly decreased, compared to the control group (p < 0.05). In the overall quality of sleep or PSQI, significant differences were not observed between the two groups (p ≥  0.05). Conclusion: Findings of the present study reveal that consumption of grape juice can decrease side effects of radiation therapy (physical fatigue and sleep disorders) in women with breast cancer.